The Canadian Journal of Neurological Sciences Monitoring Children Treated with Carbamazepine
نویسنده
چکیده
The question of monitoring patients taking anticonvulsants has been reviewed previously. During carbamazepine monotherapy, complete blood counts (CBC) and alanine transaminase (ALT) were measured at intervals in 23 children attending a Pediatric Neurology clinic during 1990 and 1991. The results were reviewed retrospectively. The mean age was 10.3 years (SD 3.7 yrs). Prior to starting carbamazepine CBC and ALT were measured in 19 and 14 respectively. In two, high white cell counts (WCC) on the day of a seizure, were excluded from the figures. Maintenance doses were mean 13.09 mg/kg/day (SD 4.68). The patients were followed for a mean 15.6 months (SD 6.7). The results were divided into those obtained during the first 8 weeks of treatment (22 samples) and those after 8 weeks (62 samples). Drug levels showed compliance in all except for two late in their course of treatment.
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